Alteplase

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

AlteplaseEMERGENCY KITEmergency Drugs

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Alteplase: indication-specific regimens
Indication	Dose	Route	Frequency	Duration / preparation	Maximum	Monitoring / cautions
Expert-led reperfusion decision for haemodynamically unstable massive PE; pregnancy/postpartum bleeding risks require simultaneous obstetric/critical-care input Genentech / DailyMedchecked	100 mg over 2 hours (adult Activase-labelled PE regimen)	IV infusion	One reperfusion course	2-hour course followed by monitored anticoagulation planning; arrest dosing may follow a different resuscitation protocol · Reconstitute the specific 50/100 mg vial only with the supplied preservative-free sterile water to 1 mg/mL. Gently swirl, do not shake; use a dedicated line. This PE regimen differs from stroke dosing	100 mg for the cited adult PE regimen; check local product weight limits and do not borrow an arbitrary stroke bolus schedule	Monitor Bleeding including genital/surgical/neuraxial sites, neurological status, BP, Hb and coagulation Pause/restart heparin according to APTT and the thrombolysis plan; arrange blood products and procedural alternatives Contraindications / cautions Major active bleeding, intracranial pathology/recent intracranial surgery and recent invasive procedures are major concerns In immediately fatal PE, the multidisciplinary team weighs contraindications against the risk of death; do not apply this row to stable suspected PE

Pregnancy safety

Life-threatening PE: multidisciplinary decision weighing maternal death against major bleeding.

Lactation

Acute maternal stabilisation takes priority; review ongoing treatment and infant exposure with the linked source and specialist team.