Browse clinical topics
Chronic Hypertension in Pregnancy
IN REVIEWHypertension present before conception or diagnosed <20 weeks; treat from ≥140/90 (CHAP-driven), prevent superimposed pre-eclampsia with aspirin, plan delivery around 38–39 weeks if controlled.
Obstetrics · pending verificationGestational Hypertension
IN REVIEWDe novo BP ≥140/90 after 20 weeks WITHOUT proteinuria/organ dysfunction; ~25% progress to pre-eclampsia; deliver by 37 weeks.
Obstetrics · pending verificationPre-eclampsia (without severe features)
IN REVIEWDe novo hypertension after 20 wks + proteinuria OR end-organ dysfunction; ISSHP advises avoiding “mild/severe” labels in ongoing pregnancy — stratify instead by gestation and trajectory; birth at 37 weeks for stable disease.
Obstetrics · pending verificationPre-eclampsia with Severe Features / Severe Pre-eclampsia
IN REVIEWPE plus severe-range BP, neurology, hepatic/renal/haematological involvement or pulmonary oedema. Stabilise with MgSO4 + antihypertensives, steroids if <34+6, then deliver ≥34 wks (expectancy 24–33+6 only in expert centres with intensive surveillance).
Obstetric Emergencies · pending verificationEclampsia
IN REVIEWGeneralised seizures in a woman with pre-eclampsia (any time antepartum/intrapartum/up to several days postpartum). MgSO4 halves recurrent seizures; stabilise THEN deliver. National Eclampsia Registry: >50% antepartum, ~13% postpartum.
Obstetric Emergencies · pending verificationHELLP Syndrome
IN REVIEWHaemolysis + Elevated Liver enzymes + Low Platelets — a variant of severe pre-eclampsia that may present WITHOUT marked hypertension. Birth is definitive; transfuse selectively; beware misdiagnosis as gastritis/hepatitis.
Obstetric Emergencies · pending verificationPostpartum Hypertension & Postpartum Pre-eclampsia
IN REVIEWBP can peak 3–6 days postpartum even after normotensive pregnancies; de novo postpartum PE occurs. Monitor, treat ≥150/95 (or lower threshold per chronic-HTN logic), choose lactation-compatible agents.
Obstetrics · pending verificationPostpartum Haemorrhage (PPH)
IN REVIEWRecognise PPH early: measured loss ≥500 mL, or ≥300 mL with abnormal haemodynamics; treat concerning ongoing bleeding/shock immediately. Resuscitation, uterotonics, early TXA and 4Ts source control proceed together, with timely tamponade or surgery.
Obstetric Emergencies · pending verificationPlacenta Praevia & Low-lying Placenta (APH pathway)
IN REVIEWPainless bright-red APH after 20 wks with malpresentation/high presenting part. NEVER digital examination. Localise with ultrasound; plan birth: resolve by 32 wks if minor/low-lying; caesarean for true praevia ~36–37 wks.
Obstetrics · pending verificationPlacental Abruption
IN REVIEWPremature separation — PAINFUL tense uterus ± dark bleeding ± fetal distress. Hidden losses mislead; DIC is the killer. Delivery decision dominates management; steroids <34, MgSO4 <32, aggressive coagulation support.
Obstetric Emergencies · pending verificationVasa Praevia
IN REVIEWFetal vessels traversing membranes over the os — ROM tears them → exsanguinating FETAL blood loss with sinus bradycardia. Antenatal detection (TVS colour Doppler) converts a catastrophe into a planned 35-week caesarean.
Obstetrics · pending verificationPlacenta Accreta Spectrum (acreta/increta/percreta)
IN REVIEWAbnormal placental invasion through the decidua — the modern maternal-surgery killer (praevia + previous caesarean is the classic setup). OUTCOME IS PLANNED: detect on imaging, refer to a centre with blood bank + IR + urology, deliver electively 35–37 wks with multidisciplinary team.
Obstetrics · pending verificationPregnancy of Unknown Location (PUL)
IN REVIEWPositive pregnancy test with no pregnancy visualised on TVS. It is a DESCRIPTION, not a diagnosis. Serial hCG + review until location declared; ~7–20% are ectopic.
Early Pregnancy & Abortion Care · pending verificationEctopic Pregnancy
IN REVIEWImplantation outside endometrial cavity (95% tubal). Rupture kills young women — ANY reproductive-age woman with pain+bleeding has an ectopic until proven otherwise. Choose expectant/medical/surgical by stability, hCG, size, heartbeat.
Obstetric Emergencies · pending verificationMiscarriage Management (threatened/incomplete/missed)
IN REVIEWOffer ALL three management routes (expectant, medical, surgical) where safe. Medical: mifepristone+miso or miso-alone regimens. Surgical: MVA/EVA under analgesia. Watch: sepsis, heavy bleeding, Rh prophylaxis, psychological care.
Early Pregnancy & Abortion Care · pending verificationRecurrent Miscarriage
IN REVIEW≥3 early losses, not necessarily consecutive (consider earlier assessment by clinical context): investigate APS, parental karyotypes, thyroid/PCOS/anatomical factors; evidence-supported treatments: progesterone for bleeding+prior loss (PRISM), LMWH+aspirin ONLY for APS.
Early Pregnancy & Abortion Care · pending verificationMolar Pregnancy & Gestational Trophoblastic Disease
IN REVIEWConfirm molar histology, arrange safe uterine evacuation and register hCG follow-up. Partial and complete moles have different surveillance after hCG normalisation; plateauing/rising hCG requires trophoblastic-centre assessment.
Gynaecological Oncology · pending verificationMedical Termination of Pregnancy — Indian Legal Framework
IN REVIEWVERIFIED against Gazette (Aug 2026): ≤20 wks needs ONE RMP; >20–24 wks needs TWO RMPs for Rule 3B categories; >24 wks ONLY via State Medical Board for substantial foetal abnormalities; NO upper limit where woman’s life at risk. Section 5A confidentiality is statutory.
Early Pregnancy & Abortion Care · pending verificationLabour Management (term)
IN REVIEWTerm labour care per NICE NG235 (updated Jun 2026): one-to-one care, partogram, conservative measures before oxytocin, continuous support. Recognise dystocia early; augment judiciously; active third stage for everyone.
Obstetrics · pending verificationInduction of Labour (IOL)
IN REVIEWBishop <7 needs ripening: prostaglandins OR balloon catheter (lower hyperstimulation). Membrane sweep from term. Failed induction is DEFINED then reassessed - not an automatic caesarean.
Obstetrics · pending verificationCaesarean Section
IN REVIEWClassify URGENCY (Lucas 1-4). Single-dose IV antibiotic BEFORE incision cuts infection ~40%. ERAS bundle: warming, VTE prophylaxis, early feeding, opioid-sparing analgesia with TAP blocks.
Obstetrics · pending verificationVBAC / TOLAC
IN REVIEWOne prior lower-segment caesarean, no contraindications -> OFFER TOLAC (success 72-75%; rupture ~0.5%). Excluded: classical/J scar, prior rupture, extensive transfundal surgery. Continuous CTG + instant theatre are non-negotiable.
Obstetrics · pending verificationShoulder Dystocia
IN REVIEWHead delivers; anterior shoulder impacts behind symphysis (turtle sign). CALL HELP then McRoberts + suprapubic pressure resolves most; then internal manoeuvres. Record times. Expect PPH and neonatal review.
Obstetric Emergencies · pending verificationCord Prolapse
IN REVIEWCord beside/below presenting part after ROM -> relieve compression NOW, birth FAST. Knee-chest/Sims tilt, bladder fill, manual elevation, category-1 caesarean unless vaginal birth imminent.
Obstetric Emergencies · pending verificationBreech Presentation & ECV
IN REVIEWOffer ECV 36+0 wks (nullip) / 37+0 (multip): success ~50-60%. Vaginal breech only for selected cases by experienced attenders under strict criteria; otherwise planned caesarean ~39 wks.
Obstetrics · pending verificationCTG Interpretation & Intrauterine Resuscitation
IN REVIEWClassify systematically: baseline, variability, accelerations, decelerations vs contractions. NORMAL/SUSPICIOUS/PATHOLOGICAL categories drive action. Pathological = conservative measures x30 min then escalate; bradycardia = act within minutes.
Obstetrics · pending verificationThreatened Preterm Labour (<37 weeks with contractions, unchanging cervix)
IN REVIEWRegular contractions WITHOUT cervical change are often false labour. Objective testing (transvaginal cervical length; fFN where available) prevents unnecessary admissions and treatments.
Obstetrics · pending verificationEstablished Preterm Labour (<37 weeks, cervical change)
IN REVIEWSteroids <34 (+/-34+6), MgSO4 neuroprotection <30-32, nifedipine tocolysis ONLY to complete these + transfer. GBS prophylaxis per protocol. Birth in right place beats heroic delay.
Obstetrics · pending verificationPPROM (Preterm Prelabour Rupture of Membranes 24+0-36+6)
IN REVIEWConfirm rupture, exclude labour/infection, then EXPECTANCY with latency antibiotics (erythromycin 250 mg QDS x10 days per GTG73), steroids, surveillance for chorioamnionitis; deliver ~34 wks (individualise 30-36+6).
Obstetrics · pending verificationTerm PROM (>=37 weeks)
IN REVIEWConfirm rupture; offer choice of induction (usually within 24 h) vs supervised waiting 24 h if GBS-negative and reassuring. GBS-positive/recent positive screen -> induction + intrapartum penicillin.
Obstetrics · pending verificationFetal Growth Restriction / SGA
IN REVIEWSGA = size <10th centile; FGR = failure to reach genetic potential (pathology). Doppler-driven management: UA/MCA/DV surveillance, steroids <34+6 at risk of birth, MgSO4 <32, deliver by severity trajectory - not by centile alone.
Obstetrics · pending verificationMultiple Pregnancy (twins incl. TTTS/TAPS/TRAP)
IN REVIEWChorionicity at 11-13+6 wks is destiny-defining: DCDA surveillance q4 wks; MCDA q2 wks from 16 wks (TTTS screening); MCMA inpatient from 26-28 wks typical. Delivery timing: DCDA 37-38, MCDA 36-37 (+/-34-37 range), MCMA ~32-34.
Obstetrics · pending verificationReduced Fetal Movements
IN REVIEWNever dismiss. Assessment = CTG + US (growth/fluid/Doppler as indicated). Recurrent RFM warrants structured follow-up; associated with stillbirth risk elevation.
Obstetrics · pending verificationGestational Diabetes Mellitus
IN REVIEWThe India programme tests all pregnancies at the first ANC and repeats a negative early test at 24–28 weeks. Record the diagnostic framework: its non-fasting 75 g method differs from a fasting OGTT. Nutrition, monitoring and individualised medication follow diagnosis; plan birth and postpartum testing.
Medical Disorders in Pregnancy · pending verificationPregestational Diabetes (T1/T2)
IN REVIEWNICE advises a preconception HbA1c below 6.5% when achievable without problematic hypoglycaemia. Assess retinal/renal disease, review pregnancy-inappropriate medicines, and plan individual insulin, glucose monitoring, birth and postpartum dose changes.
Medical Disorders in Pregnancy · pending verificationThyroid Disease in Pregnancy
IN REVIEWTreat overt hypothyroidism with TFT-guided levothyroxine. Graves treatment uses the lowest effective antithyroid dose, with PTU favoured early and a possible carbimazole switch beyond 20 weeks. Thyroid storm requires ICU-led treatment with attention to cardiac function, liver risk and iodine timing.
Medical Disorders in Pregnancy · pending verificationAnaemia in Pregnancy (Iron/Folate/B12)
IN REVIEWAssess anaemia using the gestational reference range and confirm iron deficiency rather than assuming every microcytic anaemia is IDA. Distinguish preventive iron/folate from treatment; calculate the full IV replacement need and review response.
Medical Disorders in Pregnancy · pending verificationVTE in Pregnancy (DVT/PE + Thromboprophylaxis)
IN REVIEWSuspect PE -> LMWH immediately pending imaging in most stable patients. Weight-based enoxaparin. Neuraxial rules: prophylactic dose 12 h before/4 h after epidural-spinal (24h therapeutic). Continue >=6 wks postpartum; breastfeeding-compatible.
Obstetric Emergencies · pending verificationMaternal Sepsis
IN REVIEWPregnancy-specific triggers (septic abortion, chorioamnionitis, endometritis, mastitis necrosis, UTI/pyelo). Sepsis Six adapted: cultures+lactate, broad antibiotics within 1 h, fluids, oxygen as needed, source control (EVACUATE retained products!), hourly reassessment.
Obstetric Emergencies · pending verificationHyperemesis Gravidarum
IN REVIEWPUQE scoring guides severity. Rehydrate (thiamine BEFORE dextrose!), pyridoxine+doxylamine/pyridoxine monotherapy first line, add ondansetron/promethazine/metoclopramide ladder; steroids late-resort; thromboprophylaxis when immobile.
Medical Disorders in Pregnancy · pending verificationIntrahepatic Cholestasis of Pregnancy
IN REVIEWPruritus (palms/soles) + raised bile acids WITHOUT rash/other liver cause. Ursodeoxycholic acid improves itch (not clearly outcomes). Fetal risk rises with bile acids >100 µmol/L; individualise delivery timing ~35-38+ wks by severity.
Medical Disorders in Pregnancy · pending verificationChronic Medical Disorders Quick-Reference (asthma · epilepsy · cardiac · CKD · SLE/APS)
IN REVIEWContinuity beats novelty: keep effective pre-pregnancy regimens (with teratogen switches), monitor organ function each trimester, plan birth in appropriately equipped units.
Medical Disorders in Pregnancy · pending verificationUTI & Pyelonephritis in Pregnancy
IN REVIEWScreen asymptomatic bacteriuria (treat ALL positive - pyelo/preterm risk). Cystitis: nitrofurantoin/cephalexin courses. Pyelonephritis = ADMISSION + IV ceftriaxone; preterm-labour watch.
Infections in Pregnancy · pending verificationChorioamnionitis / Intra-amniotic Infection
IN REVIEWFever >=38 intrapartum or maternal/fetal tachycardia+foul liquor: antibiotics NOW + expedite birth. Ampicillin+gentamicin(+metronidazole post-CS). Neonatal team alerted.
Infections in Pregnancy · pending verificationGBS Colonisation (prevention of early-onset neonatal disease)
IN REVIEWRectovaginal screening 36-37 wks where policy-based; risk-based approach where not. Intrapartum benzylpenicillin for positives/risk factors.
Infections in Pregnancy · pending verificationSyphilis in Pregnancy
IN REVIEWUniversal early screening (India programme) + third-trimester repeat in high-risk. Penicillin is the ONLY fetal-safe curative agent - desensitise if allergic. Treat stage-appropriately; partner management; follow-up titres.
Infections in Pregnancy · pending verificationChlamydia in Pregnancy
IN REVIEWAzithromycin 1 g PO single dose (doxycycline CONTRAINDICATED in pregnancy). Re-test 4 weeks post-completion; partner treatment; re-screen T3 high-risk.
Infections in Pregnancy · pending verificationGonorrhoea in Pregnancy
IN REVIEWCeftriaxone 500 mg IM single dose (<150 kg; 1 g >=150 kg) + chlamydia cover if unexcluded. Test-of-cure NAAT 2 wks (pregnancy-specific recommendation).
Infections in Pregnancy · pending verificationGenital Herpes in Pregnancy
IN REVIEWFirst episode: acyclovir 400 mg TDS x7-10d + suppressive acyclovir from 36 wks for recurrent-genital-HSV mothers. Active lesions AT BIRTH -> caesarean offered (primary episode esp.).
Infections in Pregnancy · pending verificationVaginitis Bundle (BV · candidiasis · trichomoniasis)
IN REVIEWTreat the diagnosed cause: symptomatic BV, Candida and trichomoniasis have different regimens. Use the complete seven-day oral metronidazole/BV-alternative cards or the pregnancy topical-azole course; trichomoniasis also needs partner care.
Infections in Pregnancy · pending verificationPelvic Inflammatory Disease
IN REVIEWLow threshold to treat. Outpatient (uncomplicated): ceftriaxone 500 mg IM x1 + doxycycline 100 BD x14 d + metronidazole 500 BD x14 d (CDC 2021 PID). Inpatient criteria incl. TOA/pregnancy/severe. TOA >5 cm or rupturing -> drainage.
Infections in Pregnancy · pending verificationViral Infections Quick-Reference (HIV · HBV · HCV · rubella · CMV · varicella · influenza · COVID)
IN REVIEWKey actions: universal HIV/HBV/HCV screening; ART for all HIV+ (viral suppression = near-zero transmission); HBV immunoglobulin+vaccine to newborns of HBsAg+ mothers; NO live vaccines in pregnancy (MMR/varicella) - immunoglobulin post-exposure instead; influenza vaccine safe & recommended; COVID current-era management per national guidance.
Infections in Pregnancy · pending verificationAbnormal Uterine Bleeding (PALM-COEIN)
IN REVIEWClassify PALM-COEIN after excluding pregnancy/cervical/endometrial pathology by age/risk. Acute heavy bleeding: resuscitate -> TXA -> hormonal stop ladder -> D&C if failing. Chronic HMB: LNG-IUS first-line medical where suitable.
Gynaecology · pending verificationPolycystic Ovary Syndrome
IN REVIEW2 of 3 criteria (hyperandrogenism/OV dysfunction/PCOM-or-elevated AMH in adults). Lifestyle foundation. Menstrual control COCP/progestogens; metformin metabolic; LETROZOLE first-line ovulation induction (2023 guideline, high certainty).
Gynaecology · pending verificationEndometriosis
IN REVIEWDysmenorrhoea/dyspareunia/chronic pain ± subfertility. Empirical hormonal suppression reasonable with negative imaging; laparoscopy diagnostic+therapeutic; post-surgical suppression reduces recurrence.
Gynaecology · pending verificationUterine Fibroids
IN REVIEWManage by symptoms/fertility/location: medical as AUB module; hysteroscopic resection submucous FIGO 0-1; myomectomy fertility-preserving; UAE completed families alternative; hysterectomy definitive.
Gynaecology · pending verificationAdnexal Masses, Ovarian Cysts & Torsion
IN REVIEWFunctional cysts observe/reimage 6-12 wks. Risk scoring directs oncology referral. TORSION = emergency laparoscopy with DETORSION (ovary-sparing standard); normal Doppler does NOT exclude.
Gynaecology · pending verificationUrogynaecology Core (SUI · OAB · POP · rUTI · fistula)
IN REVIEWSUI: supervised PFMT 3 months first, then sling/colposuspension. OAB: bladder training -> antimuscarinic/mirabegron -> specialist therapies. POP: PFMT+pessary vs repair. Fistula: catheter drainage then specialist repair centres.
Urogynaecology · pending verificationMenopause, Perimenopause & POI
IN REVIEWIndividualise HRT: uterus intact = estrogen+progestogen; hysterectomy = estrogen-only; POI = replacement AT LEAST to average natural menopause age. Vaginal estrogen safe long-term. EVERY postmenopausal bleed investigated.
Gynaecology · pending verificationEndometrial Cancer
IN REVIEWPMB workup -> biopsy. Staged per FIGO 2023 (molecular classes POLEmut/MMRd/NSMP/p53abn integrated; IAm/IICm annotations). Surgery core; adjuvant by risk group per ESGO-ESTRO-ESP Update 2025.
Gynaecological Oncology · pending verificationCervical Cancer
IN REVIEWScreening-detected CIN vs invasive cancer pathways diverge at histology. FIGO 2018 clinical staging drives therapy: early = radical hysterectomy; locally advanced = concurrent chemoradiation (cisplatin-based standard). India: HPV vaccination + VIA/screening scale-up national priority.
Gynaecological Oncology · pending verificationCervical Screening & HPV (incl. vaccination)
IN REVIEWIndia lacks universal organised screening - opportunistic VIA/Pap/HPV testing per national cancer-programme guidance; WHO elimination strategy: HPV vaccination girls 9-14 + lifetime screening targets. Abnormal results -> colposcopy pathway with defined biopsy/treatment rules.
Gynaecology · pending verificationOvarian · Vulval · Vaginal Cancer & GTN Index
IN REVIEWAdnexal mass with malignancy markers -> direct oncology referral (avoid incomplete surgery outside centres). Ovarian: cytoreductive surgery + platinum chemo backbone. Vulval/vaginal: stage-based surgery±radiotherapy. GTN: hCG registry + single/multi-agent chemo at trophoblastic centres (>90% cure).
Gynaecological Oncology · pending verificationContraception Master Module
IN REVIEWEffectiveness hierarchy favours LARC. WHO MEC categories guide eligibility by condition. Postpartum: PPIUCD/POP/DMPA anytime; implant anytime; COCP delayed 6 wks breastfeeding. Emergency contraception: copper IUD gold standard; LNG 1.5 mg within 72 h (or 3 d window); ulipristal where available.
Contraception & Infertility · pending verificationFemale Infertility Evaluation & Management
IN REVIEWStructured workup at 12 m trying (<35 y) or 6 m (>=35). Ovulation status, semen analysis FIRST, tubal patency (HSG/hyCoSy), ovarian reserve contextualised. Treat cause: letrozole-first OI for anovulation (PCOS 2023), gonadotrophins second line, ART escalation.
Contraception & Infertility · pending verificationAntenatal care: trimester tests & visit schedule
IN REVIEWPlan at least 8 WHO antenatal contacts: 1 in the first trimester, 2 in the second and 5 in the third, with extra reviews for risk or symptoms. Use the trimester tables for booking tests, scheduled repeats, scan windows and the India glucose-testing method; give every result a follow-up plan.
Antenatal Care · pending verification