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Infections in Pregnancy

Vaginitis Bundle (BV · candidiasis · trichomoniasis)

IN REVIEWv3🌍 International referencePENDING CLINICAL VERIFICATION
Treat the diagnosed cause: symptomatic BV, Candida and trichomoniasis have different regimens. Use the complete seven-day oral metronidazole/BV-alternative cards or the pregnancy topical-azole course; trichomoniasis also needs partner care.

Admission & discharge ↓

Reviewer note: Medication regimens and dependent emergency instructions checked 17 October 2026. These targeted checks do not certify every statement in the module. Admission/discharge guidance checked 18 October 2026. This adds a scoped clinical synthesis and does not certify every statement in the module.

Clinical detail

Additional detail checked 2026-10-17 against the linked sources. This check covers the section below; the rest of the module retains its displayed verification status.

Discharge, odour, itch and dysuria overlap between bacterial vaginosis, candidiasis, trichomoniasis and noninfective causes. Identify the syndrome before choosing a regimen, and separate pregnancy from nonpregnancy prescribing.

Assessment & interpretation

  • Record discharge characteristics, vulval inflammation, vaginal pH and microscopy or NAAT where appropriate. Pelvic pain, fever or cervical tenderness needs assessment beyond simple vaginitis.
  • Use culture or further assessment for persistent or complicated candidiasis rather than repeatedly prescribing empirical treatment.

Decisions that change management

  • Symptomatic bacterial vaginosis in pregnancy should be treated. One CDC regimen is metronidazole 500 mg orally twice daily for 7 days.
  • For vulvovaginal candidiasis in pregnancy, use a topical azole course for 7 days; avoid oral fluconazole. An example is clotrimazole 1% cream, 5 g intravaginally once daily for 7 days.
  • For trichomoniasis in women, use metronidazole 500 mg orally twice daily for 7 days. Symptomatic pregnant patients should be tested and treated.

Follow-up & safety-netting

  • Trichomoniasis needs partner treatment, abstinence until treatment is completed and symptoms resolve, and repeat testing at approximately 3 months.
  • Persistent symptoms require reassessment of the diagnosis, adherence, exposure and possible resistance.

Clinical pitfalls

  • Do not apply trichomoniasis partner-management instructions indiscriminately to candidiasis or bacterial vaginosis.

Admission & discharge

Care setting: Usually outpatient; systemic/pelvic symptoms require another diagnosis to be assessed

Admission/discharge guidance checked 2026-10-18 against the linked sources. This is a clinical checklist for an individual decision, not an automatic discharge order.

When admission or continued hospital care is needed

  • Fever, severe pelvic/abdominal pain, systemic illness, pregnancy fluid-loss concern or inability to tolerate treatment needs assessment for another/complicated condition.

When clinic, day care or home care may be suitable

  • Uncomplicated BV, candidiasis or trichomoniasis does not normally require admission. Identify the cause rather than treating every discharge with every drug.

Before going home

  • The diagnosis, pregnancy-appropriate treatment and return advice are clear; follow-up is arranged for persistent/recurrent or uncertain symptoms.

Discharge medicines and treatment changes

  • Use the regimen for the confirmed/likely organism. In pregnancy use the selected topical azole course for candidiasis; do not substitute routine oral fluconazole.
  • Partner treatment/retesting is relevant to trichomoniasis, not automatically to every cause of vaginitis.

Tests, pending results and their reviewer

  • Assign microbiology/STI results and arrange review if tests or symptoms do not fit the presumed diagnosis.

Home care and counselling

  • Discuss treatment completion, avoiding irritants and relevant partner/STI advice.

Follow-up: when and what to review

WhenAction / responsible service
If symptoms persist or recur
Reassess the diagnosis and treatment rather than repeatedly self-treating.
About 3 months after trichomoniasis treatment
Retest sexually active women for reinfection under the CDC pathway.

Return urgently

  • Fever, severe pain, fainting, bleeding or suspected membrane rupture requires prompt assessment.

Open the complete discharge checklist →

Treatment

① Immediate stabilization — first minutes
③ First-line treatment & drug regimens

Establish whether symptoms are due to BV, Candida, trichomoniasis or another cause before selecting a course. The cards below separate treatment choices; they are not a combination to give every patient.

④ Drug treatment detail (4 agents)
Metronidazole — bacterial vaginosisCDC · 2021 STI guidelinechecked
Dose500 mg
RouteOral
FrequencyTwice daily
Duration7 days
PreparationOne 500 mg tablet each dose. Alternative formulations/regimens must be prescribed separately
Max dose1 g/day for 7 days in this CDC regimen
  • Indication: Symptomatic BV, including pregnancy where treatment is indicated
  • CDC does not require routine alcohol abstinence on evidence of a disulfiram-like interaction; product leaflets may give different advice. Follow the dispensed product instructions and discuss the difference.
Monitoring
  • Symptoms and tolerance; recurrent symptoms need reassessment, not indefinite repeat courses
Contraindications: Nitroimidazole allergy; review warfarin, lithium and severe hepatic disease
Clindamycin — oral BV alternativeCDC · 2021 STI guidelinechecked
Dose300 mg
RouteOral
FrequencyTwice daily
Duration7 days
Preparation300 mg capsule or two 150 mg capsules per dose; swallow with a full glass of water
Max dose600 mg/day in this BV regimen, separate from 900 mg IV emergency dosing
  • Indication: Symptomatic bacterial vaginosis when an oral alternative is appropriate
  • Do not shorten this CDC pregnancy BV course to five days.
Monitoring
  • Symptom response, intolerance and severe/persistent diarrhoea suggestive of C. difficile
Contraindications: Clindamycin/lincomycin allergy; previous antibiotic-associated colitis needs careful assessment
Metronidazole — trichomoniasis in womenCDC · 2021 STI guidelinechecked
Dose500 mg
RouteOral
FrequencyTwice daily
Duration7 days
PreparationOne 500 mg tablet each dose; assess vomiting/adherence
Max dose1 g/day for this 7-day regimen
  • Indication: Trichomoniasis, including symptomatic pregnant women
Monitoring
  • Treat partner(s), avoid sex until both treatment courses complete and symptoms resolve, and retest women at about 3 months
Contraindications: Nitroimidazole allergy; review interactions and hepatic impairment
Clotrimazole — vaginal candidiasis in pregnancyCDCchecked
Dose5 g of 1% vaginal cream (50 mg clotrimazole)
RouteIntravaginal
FrequencyOnce daily, usually at bedtime
Duration7 days in pregnancy
PreparationUse a product intended for VAGINAL use with a measured 5 g dose; 1% cream is not interchangeable with a 2% three-day course or external vulval cream. Discuss insertion technique in pregnancy using the actual product instructions
Max doseOne 5 g application/day for this regimen; persistent/recurrent disease needs assessment rather than repeated blind treatment
  • Indication: Symptomatic confirmed/suspected vulvovaginal candidiasis; reconsider other diagnoses with persistent symptoms
  • CDC recommends topical azoles for seven days during pregnancy. Check product effects on latex contraception.
Monitoring
  • Symptom response, local irritation and recurrence; culture/speciation when complicated or refractory
Contraindications: Clotrimazole allergy; avoid oral fluconazole during pregnancy and do not use vaginal boric acid as a routine pregnancy alternative
Monitoring
  • Symptom resolution review; recurrent candida: glucose screen + longer maintenance topical
Post-treatment care
  • Avoid douching practices; hygiene counselling

Diagnosis & assessment

Red flags:
  • Haemodynamic instability -> sepsis pathway

Initial assessment

See treatment table for testing and regimens.

Principles & follow-up

Management principles

Sources (10)

CDC (USA) — Sexually Transmitted Infections Treatment Guidelines, 2021
2021-07 · updated 2025-12-22 (page review; guidance itself unchanged) · checked 2026-08-23 · verified-live
Open source ↗

CDC pages + wall chart: uncomplicated gonorrhoea cervix/urethra/rectum → ceftriaxone 500 mg IM single dose (<150 kg; 1 g if ≥150 kg); pharyngeal same; conjunctivitis 1 g IM; DGI 1 g IV/IM q24h; PID outpatient → ceftriaxone 500 mg IM ×1 + doxycycline 100 BD ×14 d + metronidazole 500 BD ×14 d; chlamyd…

CDC — STI Treatment Guidelines — bacterial vaginosis
· checked 2026-10-18 · verified-live
Open source ↗

Scope: additional clinical-detail explanation for vaginitis. Checked the assessment, management-decision and follow-up statements in that section against this source. This does not certify all pre-existing regimens, calculations or recommendations in the module. Additional admission/discharge check …

CDC — STI Treatment Guidelines — vulvovaginal candidiasis
· checked 2026-10-18 · verified-live
Open source ↗

Scope: additional clinical-detail explanation for vaginitis. Checked the assessment, management-decision and follow-up statements in that section against this source. This does not certify all pre-existing regimens, calculations or recommendations in the module. Additional admission/discharge check …

CDC — STI Treatment Guidelines — trichomoniasis
· checked 2026-10-18 · verified-live
Open source ↗

Scope: additional clinical-detail explanation for vaginitis. Checked the assessment, management-decision and follow-up statements in that section against this source. This does not certify all pre-existing regimens, calculations or recommendations in the module. Additional admission/discharge check …

CDC — Vulvovaginal candidiasis: pregnancy treatment
· checked 2026-10-17 · verified-live
Open source ↗

1% clotrimazole vaginal cream 5 g/day and pregnancy-specific seven-day topical azole recommendation; avoid oral fluconazole in pregnancy and evaluate persistent symptoms.

NICE — Postnatal care — NG194
· checked 2026-10-18 · verified-live
Open source ↗

Maternal/newborn transfer assessment, first void and effective feeding, handover, support/safeguarding, first midwife visit within 36 hours after transfer, postnatal danger symptoms. Full recommendations page read.

India MoHFW / NHM — District Hospital Standard Operating Procedures — LaQshya
· checked 2026-10-18 · verified-live
Open source ↗

Normal-delivery discharge not less than 48 hours: full primary SOP PDF normal-delivery/discharge passages read. Corroborated by NHM CEmONC 2024 Part 1, chapter 8. This does not define a universal post-caesarean or complicated-case stay.

WHO — WHO recommendations on quality postnatal care — official recommendation summary
· checked 2026-10-18 · verified-live
Open source ↗

Official WHO summary read: at least 24-hour facility care after birth; additional contacts at 48–72 hours, 7–14 days and week 6; individual assessment/support. Summary facts only, not a claim that the full 242-page PDF was reviewed.

RCOG — Laparoscopy — recovering well
· checked 2026-10-18 · verified-live
Open source ↗

Full primary patient recovery page read: pain control, wounds, activity/VTE, urinary/bowel and infection warning signs, adult support and no driving/important decisions during the first 24 hours after general anaesthesia. Used as general recovery/handover principles, not operation-specific discharge…

NICE — Acutely ill adults in hospital — CG50
· checked 2026-10-18 · verified-live
Open source ↗

Full primary recommendations read, focusing on critical-care-to-ward transfer: structured written handover, shared plan, monitoring, rehabilitation and receiving-team capability. Step-down is distinct from home discharge; no universal organ-support discharge cutoff is asserted.