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Infections in Pregnancy

Viral Infections Quick-Reference (HIV · HBV · HCV · rubella · CMV · varicella · influenza · COVID)

IN REVIEWv2🌍 International referencePENDING CLINICAL VERIFICATION
Key actions: universal HIV/HBV/HCV screening; ART for all HIV+ (viral suppression = near-zero transmission); HBV immunoglobulin+vaccine to newborns of HBsAg+ mothers; NO live vaccines in pregnancy (MMR/varicella) - immunoglobulin post-exposure instead; influenza vaccine safe & recommended; COVID current-era management per national guidance.

Admission & discharge ↓

Reviewer note: Condensed index module; full expansions queued v1.1 with NACO/WHO/CDC cross-checks. Admission/discharge guidance checked 18 October 2026. This adds a scoped clinical synthesis and does not certify every statement in the module.

Admission & discharge

Care setting: Most stable cases need specialist outpatient coordination; severe infection needs admission

Admission/discharge guidance checked 2026-10-18 against the linked sources. This is a clinical checklist for an individual decision, not an automatic discharge order.

General triage and discharge handover for a multi-virus index. HIV/HBV prophylaxis, antiviral courses and infection-specific testing require the separate specialist pathway; they are not replaced by this checklist.

When admission or continued hospital care is needed

  • Respiratory compromise, severe dehydration, encephalopathy, acute liver failure concern, sepsis or obstetric/fetal deterioration requires urgent hospital assessment.

When clinic, day care or home care may be suitable

  • A positive viral screen or uncomplicated infection does not by itself mandate admission. The actual virus, gestation, maternal condition and fetal/newborn risk determine care.

Before going home

  • Maternal illness is stable, required antiviral/other treatment is accessible and relevant infection-control and fetal/neonatal plans are documented.
  • Do not apply one discharge schedule or medicine list to all viruses in this index.

Discharge medicines and treatment changes

  • Reconcile the disease-specific antiviral/other treatment with the responsible specialist, including breastfeeding and interaction considerations. Prevention of maternal-to-child transmission needs its own documented birth/newborn plan.

Tests, pending results and their reviewer

  • Assign virology/serology, liver or other organ results and any fetal testing to a named reviewer; provide the actual review date.

Home care and counselling

  • Explain infection-specific contact precautions, warning symptoms and how to access maternity/infectious-disease advice.

Follow-up: when and what to review

WhenAction / responsible service
Before discharge
Book the relevant specialist and maternity follow-up, and communicate the newborn plan.
At the infection-specific testing/scan interval
Review results and modify the birth/prevention plan when indicated.

Return urgently

  • Breathlessness, chest pain, confusion, jaundice, persistent vomiting, reduced movements or an unwell newborn requires urgent assessment.

Open the complete discharge checklist →

Treatment

① Immediate stabilization — first minutes
③ First-line treatment & drug regimens
  • Each row above contains the actionable core; detailed dosing pages queued for v1.1 verification cycle
Monitoring
  • Viral-load schedules for HIV/HBV as per specialist programmes
Escalation
  • ID physician involvement for all complex vertical-transmission scenarios
⑮ Complications & their management
Vertical transmission events

Paediatric ID referral; registry reporting per programme

Post-treatment care
  • Postpartum vaccination catch-ups (live vaccines now allowed while breastfeeding)

Diagnosis & assessment

Red flags:
  • Haemodynamic instability -> sepsis pathway

Initial assessment

See treatment table for testing and regimens.

Principles & follow-up

Special situations
InfectionPregnancy-critical actions
HIV
ART regardless of CD4 (dolutegravir-based national programmes); mode by viral load; neonatal prophylaxis; avoid breastfeeding ONLY per national guidance context (India follows formula-replacement historically - verify current NACO)
Hepatitis B
HBsAg screen; high viral load -> tenofovir T3; neonate HBIG + vaccine within 12-24 h; breastfeeding SAFE with immunisation
Hepatitis C
DAA therapy POSTPARTUM (curative); breastfeeding OK unless cracked nipples bleeding
Rubella
Non-immune: MMR POSTPARTUM only; exposure -> Ig within window; congenital-rubella counselling
CMV
No routine treatment; hygiene counselling for seronegative mothers (toddlers!); congenital CMV specialist pathways
Varicella
Non-immune exposure: VZIG within 96-144 h; chickenpox in mother around delivery = neonatal VZIG; acyclovir for severe maternal cases; live vaccine postpartum
Influenza
Oseltamivir early for suspected flu ANY severity threshold lower in pregnancy; vaccination any trimester
COVID-19
Follow current MoHFW/national protocol; vaccination recommended; treat hypoxia aggressively (prone positioning safe)

Sources (7)

CDC (USA) — Sexually Transmitted Infections Treatment Guidelines, 2021
2021-07 · updated 2025-12-22 (page review; guidance itself unchanged) · checked 2026-08-23 · verified-live
Open source ↗

CDC pages + wall chart: uncomplicated gonorrhoea cervix/urethra/rectum → ceftriaxone 500 mg IM single dose (<150 kg; 1 g if ≥150 kg); pharyngeal same; conjunctivitis 1 g IM; DGI 1 g IV/IM q24h; PID outpatient → ceftriaxone 500 mg IM ×1 + doxycycline 100 BD ×14 d + metronidazole 500 BD ×14 d; chlamyd…

NICE — Acutely ill adults in hospital — CG50
· checked 2026-10-18 · verified-live
Open source ↗

Full primary recommendations read, focusing on critical-care-to-ward transfer: structured written handover, shared plan, monitoring, rehabilitation and receiving-team capability. Step-down is distinct from home discharge; no universal organ-support discharge cutoff is asserted.

NICE — NG255 — managing suspected sepsis in pregnant or recently pregnant people
19 November 2025 · checked 2026-10-18 · verified-live
Open source ↗

Scope: additional clinical-detail explanation for maternal-sepsis. Checked the assessment, management-decision and follow-up statements in that section against this source. This does not certify all pre-existing regimens, calculations or recommendations in the module. Additional admission/discharge …

NICE — Postnatal care — NG194
· checked 2026-10-18 · verified-live
Open source ↗

Maternal/newborn transfer assessment, first void and effective feeding, handover, support/safeguarding, first midwife visit within 36 hours after transfer, postnatal danger symptoms. Full recommendations page read.

India MoHFW / NHM — District Hospital Standard Operating Procedures — LaQshya
· checked 2026-10-18 · verified-live
Open source ↗

Normal-delivery discharge not less than 48 hours: full primary SOP PDF normal-delivery/discharge passages read. Corroborated by NHM CEmONC 2024 Part 1, chapter 8. This does not define a universal post-caesarean or complicated-case stay.

WHO — WHO recommendations on quality postnatal care — official recommendation summary
· checked 2026-10-18 · verified-live
Open source ↗

Official WHO summary read: at least 24-hour facility care after birth; additional contacts at 48–72 hours, 7–14 days and week 6; individual assessment/support. Summary facts only, not a claim that the full 242-page PDF was reviewed.

RCOG — Laparoscopy — recovering well
· checked 2026-10-18 · verified-live
Open source ↗

Full primary patient recovery page read: pain control, wounds, activity/VTE, urinary/bowel and infection warning signs, adult support and no driving/important decisions during the first 24 hours after general anaesthesia. Used as general recovery/handover principles, not operation-specific discharge…