Eclampsia
Admission & discharge
Admission/discharge guidance checked 2026-10-18 against the linked sources. This is a clinical checklist for an individual decision, not an automatic discharge order.
When admission or continued hospital care is needed
- Admit for severe/persistent hypertension, seizure or neurological symptoms, pulmonary oedema, renal/liver/platelet deterioration, significant pain or fetal compromise.
- Eclampsia/HELLP or organ-support needs require appropriate high-dependency/critical-care monitoring, with transfer after initial stabilisation when necessary.
When clinic, day care or home care may be suitable
- Antenatal outpatient care is a specialist decision only when maternal/fetal assessment and reliable surveillance support it; recent eclampsia or HELLP is not a routine outpatient pathway.
Before going home
- Postnatal NICE transfer criteria: no pre-eclampsia symptoms, BP ≤150/100 mmHg with or without treatment, and blood results stable or improving; all criteria must be met.
- Following eclampsia/HELLP, complete indicated seizure prophylaxis/monitoring and document neurological, respiratory, urine-output and blood-test recovery before considering home care. Critical-care step-down and discharge home are separate decisions.
- A seizure-free interval alone does not establish readiness: review other neurological causes, medication completion and the obstetric/critical-care course.
Discharge medicines and treatment changes
- Continue the selected oral antihypertensive. Stop methyldopa within 2 days after birth; document replacement and review.
- The prescriber should consider reduction below 140/90 and reduce below 130/80 mmHg under NICE; provide an individual written adjustment plan. Magnesium loading/infusions are inpatient treatment, not take-home medication.
Medicine doses — use only when indicated
Use the medicines selected for this patient. Listed alternatives are not instructions to prescribe all of them together. Confirm the actual remaining course, pregnancy/postnatal context and monitoring plan.
One selected oral BP option; do not prescribe every alternative together.
- Indication: Maintenance hypertension during pregnancy/postpartum
- BP/heart rate, postural symptoms; neonatal glucose/heart-rate observation after late-pregnancy exposure
Alternative/adjunct only within the documented BP plan.
- Indication: Maintenance hypertension in pregnancy/postpartum
- BP, headache, flushing, oedema and pulse
Postpartum only when prescribed, with renal function/potassium monitoring.
- Indication: After birth only; NICE recommends enalapril with maternal renal-function and potassium monitoring
- Renal / hepatic: Renal impairment requires a lower initial dose and adjustment from the product renal table, not the unadjusted 5 mg starter.
- NICE NG133 supplies the postpartum choice. Breastfeeding requires extra caution with premature/very young infants; use a suitable alternative when clinically indicated.
- BP, symptoms, creatinine/eGFR and potassium before and after initiation/dose changes; infant feeding, alertness and urine output if breastfeeding
Tests, pending results and their reviewer
- Review platelet count, transaminases and creatinine at 48–72 hours after birth/critical-care step-down; abnormal results need a repeat plan until recovery.
- At 6–8 weeks check urine protein; persistent proteinuria (1+ or more) needs a 3-month renal review and referral if kidney function is abnormal.
Home care and counselling
- Provide the BP schedule, named reviewer, medicine list and explicit severe-symptom instructions. Discuss recurrence, future-pregnancy planning and long-term cardiovascular risk.
Follow-up: when and what to review
| When | Action / responsible service |
|---|---|
If on antihypertensives: every 1–2 days for up to 2 weeks after transfer | NICE BP surveillance until off treatment with no hypertension; adapt intensity to findings. |
If not on antihypertensives: day 3–5 after birth | Check BP; repeat on alternate days if abnormal. |
2 weeks if still on treatment; 6–8 weeks for all | Review medicines, BP, recovery and urine protein; arrange renal follow-up when indicated. |
Return urgently
- Seizure, severe/persistent headache, visual disturbance, epigastric pain, dyspnoea, chest pain or severe BP: return immediately; postpartum onset can occur after discharge.
Treatment
① Immediate stabilization — first minutes
- Protect from injury, left-lateral positioning, suction and airway support; do not restrain forcibly or place objects in the mouth. Check glucose immediately. Give oxygen for hypoxaemia and assist ventilation if needed.
- Give ONE magnesium regimen from the cards: IV/IM OR IV maintenance, not both. Maintain a running magnesium dose/time record.
- Treat persistent systolic ≥160 OR diastolic ≥110 mmHg promptly with the selected acute-BP sequence. Magnesium treats seizures; it does not replace antihypertensive treatment.
- Assess reflexes, respiration and urine output throughout treatment. For toxicity: stop magnesium, support ventilation, call anaesthesia and give calcium gluconate as below.
③ First-line treatment & drug regimens
- Eclampsia: stop seizures and prevent recurrence
- Check patellar reflexes, respiratory rate and hourly urine output; monitor BP, pulse and consciousness
- Withhold magnesium for absent reflexes, respiratory rate <12/min or urine <100 mL in 4 h; obtain serum magnesium and senior review
- Stop magnesium and support ventilation for toxicity; give the calcium-gluconate antidote shown below
- Eclampsia: alternative when a reliable infusion pump and monitoring are available
- Maintenance concentration and pump rate are calculated from the prescribed 1 g/hour; independently check the preparation.
- Check patellar reflexes, respiratory rate and hourly urine output; monitor BP, pulse and consciousness
- Withhold magnesium for absent reflexes, respiratory rate <12/min or urine <100 mL in 4 h; obtain serum magnesium and senior review
- Stop magnesium and support ventilation for toxicity; give the calcium-gluconate antidote shown below
- Recurrent eclamptic convulsion after loading; reassess airway, glucose and magnesium toxicity
- Check patellar reflexes, respiratory rate and hourly urine output; monitor BP, pulse and consciousness
- Withhold magnesium for absent reflexes, respiratory rate <12/min or urine <100 mL in 4 h; obtain serum magnesium and senior review
- Stop magnesium and support ventilation for toxicity; give the calcium-gluconate antidote shown below
④ Drug treatment detail (4 agents)
- Indication: Antidote for clinically significant magnesium toxicity
- Continuous ECG/heart rate; respiratory status, reflexes and injection site; serum calcium/magnesium where available
- Indication: Persistent severe hypertension in pregnancy or postpartum (systolic ≥160 OR diastolic ≥110 mmHg)
- Check BP and pulse before and after each acute dose; fetal monitoring when appropriate
- Persistent severe BP despite the initial sequence requires senior/anaesthetic review, a different agent and HDU-level monitoring; avoid uncontrolled stacking
- Indication: Alternative for acute severe hypertension
- Renal / hepatic: Reduce doses with renal/hepatic impairment
- Check BP and pulse before and after each acute dose; fetal monitoring when appropriate
- Persistent severe BP despite the initial sequence requires senior/anaesthetic review, a different agent and HDU-level monitoring; avoid uncontrolled stacking
- Indication: Acute severe hypertension when oral dosing is appropriate
- NHM CEmONC contains an internal discrepancy: its prose caps the initial course at 30 mg, while the adjacent flowchart shows 10 mg then 20 mg then 20 mg. The app uses the 30 mg prose limit with prompt escalation; confirm the locally approved sequence.
- Check BP and pulse before and after each acute dose; fetal monitoring when appropriate
- Persistent severe BP despite the initial sequence requires senior/anaesthetic review, a different agent and HDU-level monitoring; avoid uncontrolled stacking
Non-drug treatment
- Left lateral tilt/position; padding rails
- Suction ready; bite protection
- Catheterise for strict urine output
- Quiet environment; minimise stimulation
Definitive treatment
- Recurrent seizure: reassess airway, glucose and magnesium exposure/toxicity before the additional magnesium dose. Continued convulsions require anaesthetic/ICU support and a refractory-seizure plan.
- Once maternal seizures, oxygenation and BP are controlled, plan birth irrespective of a reassuring gestational-age threshold; eclampsia is not managed by simply waiting until 34 weeks. Choose route by obstetric circumstances rather than automatic caesarean.
- Continue the chosen magnesium regimen until 24 h after birth or the last seizure, whichever is later; individualise for renal dysfunction or toxicity.
Monitoring
| Check | Standard | Action if failed |
|---|---|---|
Patellar reflex | Present | Withhold maintenance dose; assess level |
Respiratory rate | ≥12/min | Withhold; O₂; consider calcium gluconate if RR <12 + weakness |
Urine output | ≥25 mL/h | Withhold; assess renal function/fluid status |
Serum Mg²⁺ (if available) | 4–7 mg/dL therapeutic; >9–10 mg/dL toxic | Stop infusion; calcium gluconate 10% 10 mL IV over 3 min |
Response assessment
- No further seizures on maintenance
- Improving conscious level
- BP approaching target
- Stable fetal state
Treatment failure
Second-line treatment
- Airway: RSII intubation if repeated seizures/coma
- Levetiracetam 1–1.5 g IV or phenytoin 15–18 mg/kg (anaesthetist-led) as adjunct when magnesium-refractory
- Mannitol/intensive-care measures for raised ICP suspicion
Rescue treatment
Recurrent/prolonged seizures, inability to protect airway, hypoxia, pulmonary oedema, coma or organ failure: ICU/anaesthesia immediately.
Restrict maintenance fluids appropriately in severe pre-eclampsia, including drug-carrier volumes; titrate any resuscitation to clinical need and avoid fluid overload.
Procedure / surgery
Caesarean under GA if coagulopathic/refractory; regional acceptable when platelets/coags safe and seizures controlled. Neonatal team informed (hyper magnesaemia → floppy infant, respiratory support readiness).
Escalation
- ICU for: recurrent seizures, ventilation, renal failure, coagulopathy, coma
- Peripheral-centre rule: stabilise (airway+MgSO4+BP) THEN refer with escort — never transfer mid-seizure
⑮ Complications & their management
Recurrent seizures
Reload per failure pathway; check adherence to maintenance schedule
Aspiration pneumonitis
Antibiotics per sepsis pathway if fever/infiltrate; physiotherapy; O₂
Intracranial haemorrhage
CT; neurosurgery; BP 130–150 systolic; corrected coagulopathy
Acute kidney injury
Fluid stewardship; dialysis indications per ICU
Neonatal Mg toxicity
Inform paediatrics: hypotonia, respiratory depression — nursery observation
Post-treatment care
- MgSO4 maintenance continues 24 h AFTER last seizure (even if delivered)
- Postnatal BP + labs surveillance ≥48–72 h
- Counselling: recurrence risk, future-pregnancy aspirin plan
- Psychological debrief; contraception planning
Diagnosis & assessment
- THIS IS THE RED FLAG EVENT
- Recurrent seizures despite MgSO4
- Apnoea/desaturation between fits
- Injury/tongue bite/aspiration
- Stillbirth/abnormal CTG after fit
- Intracranial bleed suspicion (prolonged coma, focal deficits)
Definition: Occurrence of generalised tonic-clonic seizures in a woman with pre-eclampsia, in the absence of other neurological cause (FOGSI GCPR 2026 §3.x; atypical eclampsia recognised).
Initial assessment
- RECOGNISE: convulsion in hypertensive pregnant/postpartum woman
- CALL FOR HELP (senior obstetrician, anaesthetist; note time)
- During fit: do NOT restrain; protect from injury; nothing in mouth
- After fit: left lateral position; suction secretions; O₂ 15 L/min non-rebreather; airway adjunct if needed
- IV access ×2; send bloods (incl. Mg level baseline, coags, crossmatch)
- Start MgSO4 LOADING DOSE IMMEDIATELY (before transport/imaging)
- BP assessment + antihypertensive if ≥160/110
- Continuous fetal monitoring once maternal stabilisation under way (fetal bradycardia common transiently post-fit — observe 10–15 min before emergency caesarean unless persistent)
Investigations
| Test | Looking for |
|---|---|
CBC, platelets, coagulation | HELLP/DIC coexistence |
Creatinine, LFTs, LDH | Organ dysfunction severity |
Serum magnesium (where available) | Baseline before maintenance; toxicity checks |
SpO₂/ABG if cyanosis/desaturation | Aspiration/pulmonary oedema |
CT brain ONLY if atypical (coma >expected, focal signs, age atypical, no HTN/proteinuria) | ICH/venous sinus thrombosis/other pathology — do not delay MgSO4 |
Algorithm
Principles & follow-up
Management principles
Guideline conflict
India NHM CEmONC, chapter 4 — prose
Acute oral nifedipine: 10 mg, reassess at 20 minutes, repeat 10–20 mg; stated initial-course maximum 30 mg.
Same NHM chapter — adjacent flowchart
The flowchart shows 10 mg, then 20 mg, then another 20 mg at 20-minute reassessments, implying 50 mg.
Population/setting difference: These refer to the same severe-pregnancy-hypertension setting; this is an internal document discrepancy, not a demonstrated population difference.
Practical India consideration: Confirm the sequence formally approved in the treating unit. Extended-release maintenance tablets are a separate regimen.
Reason: This avoids silently combining incompatible limits or prolonging oral loading in uncontrolled severe hypertension.
Guideline conflict
India NHM CEmONC, chapter 4 — prose
20 mg, then 40 mg, then 80 mg at 10-minute reassessments; further dosing may reach a cumulative 300 mg.
Same NHM chapter — adjacent flowchart
Stops the displayed 20 → 40 → 80 mg sequence at a stated 140 mg maximum.
Population/setting difference: Same emergency setting; the flowchart and prose show different stopping points.
Practical India consideration: Use the approved local sequence and track every previous IV dose. Persistent severe BP needs senior/anaesthetic involvement.
Reason: A cumulative ceiling is not an instruction to continue dosing without reassessing treatment failure and contraindications.
Sources (14)
2026-01 · checked 2026-08-23 · verified-live
Open source ↗
PDF served from fogsi.org (2026 upload path) — definitions, HDP-Gestosis score, treatment threshold ≥140/90 (WOG), targets ≤140/90, delivery timing (GH term; mild PE 37 wks; severe PE after 34 wks; eclampsia deliver once stabilised post-MgSO4; ≤24 wks immediate delivery better; individualise 24–33+6…
2021 (publ 2022 Hypertension) · checked 2026-08-23 · verified-live
Open source ↗
Full PDF: standardised BP measurement; proteinuria PrCr ≥30 mg/mmol, ACR ≥8 mg/mmol or ≥300 mg/day or dipstick 2+ if confirmatory testing unavailable; no 'mild/severe' PE label in ongoing pregnancy; treat all HDP with antihypertensives; severe HTN ≥160/110 treat within minutes-hours monitored; targe…
· checked 2026-10-17 · verified-live
Open source ↗
Loading and maintenance doses, 24-hour stopping rule, recurrence ceiling, urine/reflex/respiratory monitoring and toxicity management.
· checked 2026-10-17 · verified-live
Open source ↗
10% strength, adult initial 1 g IV dose over at least 5 minutes for magnesium toxicity/severe hypocalcaemia; ECG and extravasation precautions.
· checked 2026-10-17 · verified-live
Open source ↗
Scanned primary PDF pages 103–104 examined by OCR and visual review: labetalol prose sequence/cumulative 300 mg, sustained-release nifedipine 10 mg twice daily/max 80 mg, and internal prose/flowchart differences for acute nifedipine and labetalol. The app exposes rather than merges the differences.
· checked 2026-10-17 · verified-live
Open source ↗
20 mg reconstituted/diluted to 10 mL (2 mg/mL), 5 mg over 2–4 minutes, 20-minute reassessment and cumulative 20 mg bolus regimen.
25 June 2019 · updated 17 April 2023 · checked 2026-10-18 · verified-live
Open source ↗
Scope: additional clinical-detail explanation for hdp-postpartum. Checked the assessment, management-decision and follow-up statements in that section against this source. This does not certify all pre-existing regimens, calculations or recommendations in the module. Targeted medication audit: Table…
· checked 2026-10-17 · verified-live
Open source ↗
100 mg twice daily with increments, divided higher dosing, 2400 mg/day limit and beta-blocker cautions.
· checked 2026-10-17 · verified-live
Open source ↗
Hypertension initial 5 mg with volume/renal caution, 40 mg/day maintenance ceiling, creatinine/potassium and pregnancy/feeding warnings. NICE NG133 supplies the separately cited postpartum recommendation.
· checked 2026-10-18 · verified-live
Open source ↗
Maternal/newborn transfer assessment, first void and effective feeding, handover, support/safeguarding, first midwife visit within 36 hours after transfer, postnatal danger symptoms. Full recommendations page read.
· checked 2026-10-18 · verified-live
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Normal-delivery discharge not less than 48 hours: full primary SOP PDF normal-delivery/discharge passages read. Corroborated by NHM CEmONC 2024 Part 1, chapter 8. This does not define a universal post-caesarean or complicated-case stay.
· checked 2026-10-18 · verified-live
Open source ↗
Official WHO summary read: at least 24-hour facility care after birth; additional contacts at 48–72 hours, 7–14 days and week 6; individual assessment/support. Summary facts only, not a claim that the full 242-page PDF was reviewed.
· checked 2026-10-18 · verified-live
Open source ↗
Full primary patient recovery page read: pain control, wounds, activity/VTE, urinary/bowel and infection warning signs, adult support and no driving/important decisions during the first 24 hours after general anaesthesia. Used as general recovery/handover principles, not operation-specific discharge…
· checked 2026-10-18 · verified-live
Open source ↗
Full primary recommendations read, focusing on critical-care-to-ward transfer: structured written handover, shared plan, monitoring, rehabilitation and receiving-team capability. Step-down is distinct from home discharge; no universal organ-support discharge cutoff is asserted.