ODOBGYNDECODED

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Ampicillin

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

AmpicillinEMERGENCY KITAminopenicillin

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Ampicillin: indication-specific regimens
IndicationDoseRouteFrequencyDuration / preparationMaximumMonitoring / cautions
Intra-amniotic infection, in combination with gentamicin; add anaerobic cover for caesarean according to the chosen guideline
2 g
IV infusion
Every 6 hours
Continue through birth with postpartum review; the cited Malaysian NAG continues until afebrile/asymptomatic ≥48 h. Other national protocols shorten postpartum treatment after clinical recovery · Reconstitute the actual vial per label; dilute each adult dose in 100 mL sodium chloride 0.9% or glucose 5% and infuse over 30 min. Use a separate line/flush from gentamicin
  • This is not GBS prophylaxis and is not ampicillin monotherapy. The postpartum duration differs between guidelines; record the local choice explicitly.
8 g/day in this 2 g every-6-h regimen; renal impairment requires adjustment
Monitor
  • Temperature, pulse, BP, uterine tenderness, fetal heart rate, cultures and renal function
Contraindications / cautions
  • Penicillin anaphylaxis; check severe delayed beta-lactam reactions
GBS prevention during labour when prophylaxis is indicated
2 g IV initially, then 1 g IV
IV infusion
Initial 2 g load, then 1 g every 4 hours
Continue UNTIL BIRTH; this is not a multi-day infection-treatment course · Reconstitute according to the vial; dilute the adult dose in compatible fluid and infuse over 30 min. Do not mix with gentamicin
  • Penicillin G is dosed in MILLION UNITS; its 5-million-unit loading schedule must not be copied as grams of ampicillin.
2 g loading, then 1 g per subsequent dose until birth
Monitor
  • Penicillin allergy, dose times and delivery time; do not delay necessary obstetric intervention solely to complete antibiotic hours
Contraindications / cautions
  • Penicillin anaphylaxis or severe delayed beta-lactam reaction
Pregnancy safety
Safe
Lactation
Compatible