Carboprost (PGF2alpha)

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

Carboprost (PGF2alpha)EMERGENCY KITUterotonic

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Carboprost (PGF2alpha): indication-specific regimens
Indication	Dose	Route	Frequency	Duration / preparation	Maximum	Monitoring / cautions
Refractory atonic PPH after first-line uterotonic; do not use for trauma or retained tissue alone Manufacturer prescribing information / DailyMedchecked	250 micrograms (0.25 mg) deep IM	IM only	Repeat according to response at intervals of 15–90 min; NEVER sooner than 15 min	Acute rescue; ongoing bleeding requires parallel tamponade/surgery · 250 micrograms/mL: draw 1 mL undiluted. Verify units carefully: micrograms, not milligrams. Do not administer IV	2 mg total = 8 doses of 250 micrograms	Monitor Quantified blood loss, uterine tone, BP/pulse, perfusion and urine output; record every dose and time Persistent shock or bleeding needs source control and blood products in parallel; do not wait for all drug doses Respiratory status/bronchospasm, BP, vomiting/diarrhoea Contraindications / cautions Asthma or significant active pulmonary disease; active cardiac, renal or hepatic disease Do not persist with repeated injections in a deteriorating patient

Pregnancy safety

Therapeutic use only

Lactation

Short-course compatible

Adverse effects

Bronchospasm, vomiting, diarrhoea, flushing, hypertension transient