Cefazolin

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

CefazolinFirst-generation cephalosporin

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Cefazolin: indication-specific regimens
Indication	Dose	Route	Frequency	Duration / preparation	Maximum	Monitoring / cautions
Surgical prophylaxis, not treatment of established infection ASHP / IDSA / SIS / SHEAchecked	2 g IV; 3 g for weight ≥120 kg in the cited surgical prophylaxis standard	IV infusion	Once, completed within 60 min before incision; redose for a prolonged operation or major blood loss	Single perioperative prophylaxis course; do not continue routine postoperative doses without an infection indication · Reconstitute and dilute the specific cefazolin vial according to its label; prepare a compatible IV infusion and administer over 30 min for the cited formulation. Never use an IM lidocaine diluent IV For a severe beta-lactam allergy, the cited prophylaxis standard uses clindamycin 900 mg IV PLUS gentamicin 5 mg/kg IV as a single pre-incision regimen. Confirm dosing weight/renal risk.	Initial 2 g (or 3 g ≥120 kg); redose cefazolin at 4 h if indicated, earlier after major blood loss per anaesthetic plan	Monitor Allergy history, time relative to incision, operation duration and blood loss Contraindications / cautions Severe beta-lactam allergy requires an alternative COMBINATION regimen, not clindamycin alone by default

Pregnancy safety

Safe

Lactation

Compatible