Ceftriaxone

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

CeftriaxoneEMERGENCY KITThird-gen cephalosporin

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Ceftriaxone: indication-specific regimens
Indication	Dose	Route	Frequency	Duration / preparation	Maximum	Monitoring / cautions
Gonococcal cervicitis/urethritis; add pregnancy-appropriate chlamydia treatment if not excluded CDC · 2021 STI guidelinechecked	500 mg IM once if weight <150 kg; 1 g IM once if ≥150 kg	IM	Once	Single treatment dose; partner management, test-of-cure when indicated and retesting remain necessary · Use the IM diluent specified for the exact vial; lidocaine-containing IM solution must NEVER be given IV. Reconstitution volumes vary by brand	1 g for the ≥150 kg group in this CDC regimen	Monitor Allergy, pregnancy and chlamydia status; retest at 3 months, and pharyngeal infection test-of-cure at 7–14 days Contraindications / cautions Severe cephalosporin allergy requires a specific alternative and specialist advice in pregnancy
Mild/moderate PID in a NON-PREGNANT patient suitable for outpatient treatment CDC · 2021 STI guidelinechecked	500 mg IM once, PLUS doxycycline 100 mg twice daily AND metronidazole 500 mg twice daily for 14 days	IM ceftriaxone + oral combination partners	Ceftriaxone once; partners twice daily	One ceftriaxone dose; oral partners for 14 days; reassess within 72 h · Use the vial-specific IM reconstitution. Do not use lidocaine-containing IM solution IV	If ≥150 kg with documented gonorrhoea, ceftriaxone 1 g IM (CDC). Do not repeat daily as an outpatient substitute for reassessment	Monitor Clinical improvement within 72 h, STI results, adherence, partner treatment and pregnancy test Contraindications / cautions Pregnancy, tubo-ovarian abscess, severe illness/vomiting or uncertain surgical diagnosis usually requires admission; this outpatient doxycycline regimen is unsuitable
Hospitalised PID, with appropriate combination antibiotics CDC · 2021 STI guidelinechecked	1 g IV daily, PLUS doxycycline 100 mg twice daily AND metronidazole 500 mg twice daily	IV, with oral/IV combination partners	Ceftriaxone every 24 h; partners every 12 h	Switch after clinical improvement (usually 24–48 h) to appropriate oral therapy to COMPLETE 14 days; abscess needs adequate anaerobic cover · Reconstitute with water for injection per product, dilute in 100 mL compatible sodium chloride 0.9%/glucose 5% and infuse over 30 min. No calcium-containing diluent	1 g/day in this CDC PID regimen; do not omit the combination partners	Monitor Clinical response, cultures, oral tolerance and abscess/source-control assessment Contraindications / cautions Pregnancy requires an obstetric/infection-specialist regimen; do not automatically continue doxycycline
Selected inpatient pyelonephritis in pregnancy, guided by cultures and resistance ACOGchecked	1–2 g	IV infusion	Every 24 hours	Review IV therapy by 48 h; step down when improving. ACOG uses 14 days TOTAL therapy for pregnancy pyelonephritis · Use water for reconstitution and a compatible non-calcium IV diluent; adult infusion example 100 mL sodium chloride 0.9% over 30 min. Do not give lidocaine-containing IM solution IV The NICE NG111 pregnancy table usually uses cefuroxime; this is the ACOG-compatible ceftriaxone option, not a claim that every guideline chooses the same drug.	2 g/day for this row; renal/hepatic dysfunction and severe infection need individual review	Monitor Vitals, sepsis features, renal function, cultures and clinical response within 48–72 h Contraindications / cautions Cephalosporin anaphylaxis; do not use nitrofurantoin/fosfomycin as renal-parenchymal step-down agents

Pregnancy safety

Safe

Lactation

Compatible

CDC · 2021 STI guidelinecheckedIN REVIEW