Dinoprostone

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

DinoprostoneProstaglandin E2 for induction

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Dinoprostone: indication-specific regimens
Indication	Dose	Route	Frequency	Duration / preparation	Maximum	Monitoring / cautions
Hospital induction in an eligible unscarred uterus after cervical/fetal assessment; alternative to other ripening medicines Pfizer / emcchecked	3 mg vaginally; if labour is not established, one further 3 mg tablet after 6–8 hours	Vaginal posterior fornix	Initial dose, then at most ONE repeat at 6–8 hours if eligible	One induction course, with reassessment after the maximum; stop further dosing for labour/hyperstimulation or fetal concern · Use the specific Prostin E2 3 mg VAGINAL TABLET, inserted high in the posterior fornix by trained staff. Gel and controlled-release inserts have different strengths/schedules Do not give together with misoprostol or oxytocin as a stacked ripening regimen; asthma and major cardiac/renal/hepatic disease require assessment.	6 mg total; wait at least 6 hours after dinoprostone before oxytocin	Monitor Uterine activity and fetal heart rate, maternal observations, hypertonus/tachysystole and signs of rupture; emergency obstetric cover Contraindications / cautions Previous caesarean/major uterine surgery, disproportion, malpresentation, suspected fetal distress, placenta praevia/unexplained bleeding or contraindication to labour

Pregnancy safety

Specialist hospital induction after contraindication assessment

Lactation

Short intrapartum use; reassess ongoing maternal treatment after birth