ODOBGYNDECODED

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Enalapril

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

EnalaprilAntihypertensive / ACE inhibitor

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Enalapril: indication-specific regimens
IndicationDoseRouteFrequencyDuration / preparationMaximumMonitoring / cautions
After birth only; NICE recommends enalapril with maternal renal-function and potassium monitoring
Start 5 mg once daily; use a lower supervised initial dose if volume depleted or renally impaired; titrate to BP response
Oral
Once daily initially
Review BP and dose after birth; reduce/stop as hypertension resolves or continue for persistent hypertension after medical review · 5 mg tablet swallowed with water, with or without food. Correct volume depletion; check creatinine and potassium before starting
  • NICE NG133 supplies the postpartum choice. Breastfeeding requires extra caution with premature/very young infants; use a suitable alternative when clinically indicated.
  • Renal / hepatic: Renal impairment requires a lower initial dose and adjustment from the product renal table, not the unadjusted 5 mg starter.
40 mg/day in the product label; usual maintenance 20 mg/day, not an automatic postpartum target
Monitor
  • BP, symptoms, creatinine/eGFR and potassium before and after initiation/dose changes; infant feeding, alertness and urine output if breastfeeding
Contraindications / cautions
  • Pregnancy, prior ACE-inhibitor angioedema, significant hyperkalaemia; avoid starting in unresolved AKI or severe volume depletion
Pregnancy safety
Use postpartum; do not initiate during pregnancy
Lactation
Postpartum option with infant and maternal monitoring