Gentamicin

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

GentamicinAminoglycoside

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Gentamicin: indication-specific regimens
Indication	Dose	Route	Frequency	Duration / preparation	Maximum	Monitoring / cautions
Combination therapy for chorioamnionitis, postpartum endometritis or septic miscarriage MSFchecked	5 mg/kg using the approved aminoglycoside dosing weight	IV infusion	Every 24 h initially if renal function allows; subsequent interval depends on drug levels and renal function	Daily review; limit unnecessary exposure, stop or narrow after source control and clinical recovery. Duration follows the infection, not a universal 48–72 h rule · 40 mg/mL stock: volume in mL = prescribed mg ÷40. Dilute the adult dose in 100 mL sodium chloride 0.9%/glucose 5%; infuse over 30 min. Use a separate line/flush from beta-lactams Renal / hepatic: Adjust interval/dose to renal function and measured levels; do not keep automatic daily dosing in AKI	Weight-based; do not apply total body weight uncritically in obesity. Withhold/review further doses for accumulating levels or renal deterioration	Monitor Baseline and serial creatinine/urine output; drug-level monitoring using the hospital once-daily schedule Ask about tinnitus, hearing change or vertigo; stop and review suspected ototoxicity Contraindications / cautions Aminoglycoside allergy; myasthenia gravis, AKI, prior auditory/vestibular toxicity require specialist assessment

Pregnancy safety

Use when indicated (standard); fetal ototoxicity theoretical at prolonged high levels - keep courses short

Lactation

Compatible