Unfractionated heparin

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

Unfractionated heparinEMERGENCY KITAnticoagulants

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Unfractionated heparin: indication-specific regimens
Indication	Dose	Route	Frequency	Duration / preparation	Maximum	Monitoring / cautions
Selected life-threatening PE, severe renal dysfunction or impending procedures when rapid reversibility is valuable RCOGchecked	80 units/kg IV loading, then 18 units/kg/hour; subsequent changes follow APTT/anti-Xa nomogram	IV loading + IV infusion	Continuous infusion after the initial loading dose	Until a definitive anticoagulation/reperfusion plan permits transition; duration individualised around bleeding and procedures · Example: 25,000 units made up to FINAL 50 mL sodium chloride 0.9% =500 units/mL. Pump mL/h = prescribed units/h ÷500. Independently check vial units/mL, patient weight and label	No fixed cumulative ceiling; dose to APTT/anti-Xa with the approved nomogram. Omit/review bolus after thrombolysis or when bleeding risk requires	Monitor Baseline CBC/platelets, coagulation and renal function; check APTT 6 h after starting and after dose changes Bleeding, Hb/platelets, HIT risk and procedure/neuraxial timing Contraindications / cautions Active major bleeding or HIT; recent surgery/neuraxial procedure requires a documented specialist risk plan

Pregnancy safety

Specialist-selected IV anticoagulation when rapid reversibility is needed.

Lactation

Acute maternal stabilisation takes priority; review ongoing treatment and infant exposure with the linked source and specialist team.