Metoclopramide

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

MetoclopramideDopamine antagonist antiemetic

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Metoclopramide: indication-specific regimens
Indication	Dose	Route	Frequency	Duration / preparation	Maximum	Monitoring / cautions
RCOG second-line antiemetic after assessing hydration and prior treatments Manufacturer / emcchecked	5–10 mg	Oral	Every 8 hours; leave at least 6 hours between any two doses even if vomiting	At most 5 days in the product safety restriction; reassess rather than issuing an indefinite repeat · 5 or 10 mg oral formulation; check strength. Do not automatically repeat a vomited dose before the minimum interval RCOG places this after first-line options because of extrapyramidal reactions. Renal / hepatic: CrCl 15–60: reduce daily dose by 50%; ≤15: reduce by 75%; severe hepatic impairment: reduce by 50%.	Lower of 30 mg/day or 0.5 mg/kg/day	Monitor Acute dystonia/akathisia, drowsiness, response, hydration and renal function; stop if neurological adverse effects occur Contraindications / cautions GI obstruction/perforation/bleeding, epilepsy, Parkinson disease, phaeochromocytoma, prior tardive dyskinesia; avoid with levodopa

Pregnancy safety

RCOG second-line option with neurological/short-course precautions

Lactation

Review infant effects and maternal adverse reactions; avoid prolonged unnecessary use