Mifepristone

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

MifepristoneProgesterone receptor antagonist

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Mifepristone: indication-specific regimens
Indication	Dose	Route	Frequency	Duration / preparation	Maximum	Monitoring / cautions
Priming for a combined medical-abortion course <12 weeks, within the legal and service framework WHOsummary checked	200 mg	Oral	Once, followed by misoprostol 800 micrograms 24–48 h later	One combined course; confirmation of completion and emergency access are essential · One 200 mg tablet swallowed; arrange the exact subsequent misoprostol route, time and follow-up before treatment A single dose does not require a routine breastfeeding interruption in the cited MSF monograph.	200 mg in this priming regimen; not repeated daily	Monitor Bleeding, pain, ongoing pregnancy symptoms and access to urgent review Contraindications / cautions Suspected ectopic/molar pregnancy, chronic adrenal failure, long-term systemic corticosteroid therapy or significant bleeding/anticoagulation concerns
Confirmed missed miscarriage choosing NICE medical management NICE · NG126checked	200 mg, followed 48 h later by misoprostol 800 micrograms unless the sac has passed	Oral	Once	One initial combined course · One 200 mg tablet; provide written timing and contact instructions. No mifepristone for incomplete miscarriage	200 mg initially	Monitor Symptoms, bleeding and subsequent completion assessment Contraindications / cautions Ectopic pregnancy or unconfirmed diagnosis; adrenal insufficiency or long-term systemic steroids require review

Pregnancy safety

Intended use under MTP Act framework

Lactation

The MSF monograph does not contraindicate breastfeeding after a single dose; repeated dosing needs separate advice.