Nitrofurantoin

Pregnancy & gynaecology-specific. Every dose row is source-referenced; verify against institutional protocols.

NitrofurantoinUrinary antibacterial

Regimens checked: 2026-10-17. Each indication has its own preparation, limits and safety checks.

Nitrofurantoin: indication-specific regimens
Indication	Dose	Route	Frequency	Duration / preparation	Maximum	Monitoring / cautions
Culture-guided asymptomatic bacteriuria/cystitis; not pyelonephritis NICEchecked	100 mg modified release twice daily; if unavailable, 50 mg immediate release four times daily	Oral	Use ONE formulation-specific schedule	7 days · Take with food using the specified modified-release capsule or immediate-release product; do not exchange frequency between formulations NICE routine eligibility is eGFR ≥45 mL/min; eGFR 30–44 use is exceptional and needs a specific resistance/benefit-risk assessment.	200 mg/day in either cited pregnancy lower-UTI regimen	Monitor Symptoms, culture/susceptibility, renal function and clinical response by 48 hours; stop/review pulmonary or hepatic symptoms Contraindications / cautions Avoid at term, in G6PD deficiency and significant renal impairment; fever/loin pain or sepsis requires an upper-UTI pathway

Pregnancy safety

Avoid at term and with G6PD deficiency; lower-UTI use only

Lactation

Assess infant age/G6PD status and the actual product guidance